Cell Culture Media, Supplements, and Reagents
Medchemexpress LLC Kasugamycin | 6980-18-3 | 99.8% | 1 G
Kasugamycin (Ksg) is an antibiotic that binds to both the 30S and 70S ribosome, but not isolated 50S subunits. It mimics mRNA nucleotides to destabilize tRNA binding and inhibit canonical translation initiation.
- Binds to 30S and 70S ribosomes
- Inhibits canonical translation initiation
- Destabilizes tRNA binding
- Purity of 99.82%
- Suitable for research use
Medchemexpress LLC TTA-A2 | 953778-63-7 | 99.33% | 378.39 | 10 MG
TTA-A2 is a potent, selective, and orally active T-type voltage-gated calcium channel antagonist with reduced pregnane X receptor (PXR) activation. It is equally potent against the Cav3.1 (a1G) and Cav3.2 (a1H) channels. TTA-A2 can be used for the research of a variety of human neurological diseases, including sleep disorders and epilepsy.
- Potent and selective T-type voltage-gated calcium channel antagonist
- Reduced pregnane X receptor activation
- Equally potent against Cav3.1 and Cav3.2 channels
- Useful for research into neurological diseases such as sleep disorders and epilepsy
Medchemexpress LLC VU0155041 | 1093757-42-6 | 99.10% | C14H15Cl2NO3 | 100 MG
VU0155041 is a potent and selective positive allosteric modulator (PAM) of mGluR4, with EC50s of 798 nM for human mGluR4 and 693 nM for rat mGluR4. It has potential for the research of Parkinson's disease (PD).
- Potent, selective positive allosteric modulator (PAM) of mGluR4
- EC50s of 798 nM (human mGluR4) and 693 nM (rat mGluR4)
- Does not affect NMDA receptor currents in striatal medium spiny neurons
- Reverses catalepsy induced by Haloperidol in rats
- Reverses Reserpine-induced akinesia in rats
Medchemexpress LLC Fosmidomycin sodium salt | 66508-37-0 | 99.7% | 205.08 | 50 MG
Fosmidomycin sodium salt is a phosphonic acid antibiotic and an antimalarial agent, active against both Gram-negative and Gram-positive bacteria. It has shown effectiveness in in vivo studies, with animals treated intraperitoneally or orally becoming apparently free of parasites. Mice treated for 8 days were totally cured.
- Phosphonic acid antibiotic.
- Antimalarial agent.
- Active against both Gram-negative and Gram-positive bacteria.
- In vivo studies show that animals treated intraperitoneally with dosages >10 mg/kg are apparently free of parasites.
- In vivo studies show that animals treated orally with 50 or 100 mg/kg are apparently free of parasites.
- Mice treated with 30 mg/kg over an 8-day period were totally cured.
Medchemexpress LLC Lodoxamide tromethamine | 63610-09-3 | 99.8% | 553.90 | 50 MG
Lodoxamide tromethamine (U-42585E) is a medication for the treatment and prophylaxis of mast cell-mediated allergic disease. It inhibits histamine release and ionophore-induced 45Ca influx in purified rat peritoneal mast cells. In vivo, it demonstrates cromolyn-like activity and significantly inhibits increased respiratory frequency and decreased tidal volume induced by antigen challenge. It also helps decrease lung reperfusion injury and improves breathing difficulties, cough, sputum production, and sleep.
- Treats and prevents mast cell-mediated allergic disease
- Inhibits histamine release
- Inhibits ionophore-induced 45Ca influx
- Demonstrates cromolyn-like activity
- Inhibits increased respiratory frequency and decreased tidal volume induced by antigen challenge
- Decreases lung reperfusion injury
- Improves daytime breathing difficulty, cough, sputum production, and sleep
Medchemexpress LLC Kasugamycin (hydrochloride hydrate) | 200132-83-8 | 99.9% | 500 MG
Kasugamycin (Ksg) hydrochloride hydrate is an antibiotic that binds to 30s and 70s ribosomes but not to the 50s subunit, and has anti-infective activity. It mimics mRNA nucleotides, disrupts tRNA binding and inhibits canonical translation initiation. This product also increases the sensitivity of mycobacteria to Rifampicin in vitro and in mouse infection models.
- Antibiotic
- Binds to 30s and 70s ribosomes
- Anti-infective activity
- Mimics mRNA nucleotides
- Disrupts tRNA binding
- Inhibits canonical translation initiation
- Increases sensitivity of mycobacteria to Rifampicin
Medchemexpress LLC Chloramphenicol palmitate | 530-43-8 | 98.25% | 25 MG
Chloramphenicol palmitate is an orally active prodrug of Chloramphenicol, formed by the esterification of the agent with Palmitic acid. It is rapidly and completely hydrolyzed by intestinal esterase, releasing Chloramphenicol, which is an orally effective broad-spectrum antibiotic. For research use only. MedChemExpress (MCE) does not sell to patients.
- Orally active prodrug of Chloramphenicol.
- Rapidly and completely hydrolyzed by intestinal esterase.
- Releases Chloramphenicol, an orally effective broad-spectrum antibiotic.
- In vivo, chloramphenicol palmitate (10% dry formulation; p.o.; four doses) achieves steady-state plasma chloramphenicol concentrations of 5-6 μg/mL in four female beef-type calves, with an elimination half-life of 4.5 hours (chloramphenicol).
Alkali Scientific Rapamycin, 25 Mg
Rapamycin (25mg) is a powerful cell growth inhibitor that works by blocking mTOR (mechanistic target of rapamycin), a crucial protein involved in cell metabolism, growth, and survival. This makes it a critical tool in cellular research, particularly for studying cancer, aging, and immunological responses. By inhibiting mTOR, Rapamycin prevents cells from progressing through the cell cycle, which can be useful for exploring cell signaling and growth control mechanisms. It also serves as an immunosuppressant in clinical applications, such as preventing organ rejection in transplant patients. In laboratory research, it is used for understanding the cellular impact of mTOR inhibition and its therapeutic potential.
Alkali Scientific Rapamycin, 1 Mg
Rapamycin (1mg) is a laboratory reagent primarily used as a cell growth inhibitor in biological research. It works by binding to the mTOR (mechanistic target of rapamycin) protein, inhibiting its activity and thus preventing cell division and growth. This makes it an essential tool in cancer research, immunology, and the study of cell signaling pathways. Rapamycin has also been shown to have immunosuppressive properties, making it useful in transplant medicine to prevent organ rejection. In research, it is used to explore pathways related to aging, metabolism, and diseases associated with uncontrolled cell growth, such as cancer.
Biotium HGF / SF(EGH2 4C12.1), CF647 conjugate, 0.1mg/mL
This gene encodes a protein that binds to the hepatocyte growth factor receptor to regulate cell growth, cell motility and morphogenesis in numerous cell and tissue types. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate alpha and beta chains, which form the mature heterodimer. This protein is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. This protein also plays a role in angiogenesis, tumorogenesis, and tissue regeneration. Although the encoded protein is a member of the peptidase S1 family of serine proteases, it lacks peptidase activity. Mutations in this gene are associated with nonsyndromic hearing loss. Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes